Manchego cheese is a Spanish cheese made from sheep's milk and protected by an appellation of origin in La Mancha. Has recognized the PDO at European level by Regulation (EC) 1107/96 European Commission. In 2007 it has been proposed to modify the specification for the PDO. Generally they made good pairing with the wines of La Mancha.

The area covered by the designation of origin 'Queso Manchego' is 4,419,763 hectares, in a series demunicipios covering parts of the provinces of Albacete (21.66% of the region), Ciudad Real (33.16%), Cuenca (22.13%) y Toledo (23.05%), which constitute the region of La Mancha.